Eosinophil Recruitment in Type-2 Hypersensitivity Pulmonary Granulomas
نویسندگان
چکیده
منابع مشابه
Eosinophil recruitment into sites of delayed-type hypersensitivity reactions in mice.
The selective accumulation of eosinophils in tissue is a characteristic feature of allergic diseases where there is a predominance of lymphocytes expressing a Th2 phenotype. In an attempt to define factors determining specific eosinophil accumulation in vivo, we have used a radiolabeled technique to assess the occurrence and the mechanisms underlying (111)In-eosinophil recruitment into Th1- and...
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The current paradigm surrounding allergen-mediated T helper type 2 (Th2) immune responses in the lung suggests an almost hegemonic role for T cells. Our studies propose an alternative hypothesis implicating eosinophils in the regulation of pulmonary T cell responses. In particular, ovalbumin (OVA)-sensitized/challenged mice devoid of eosinophils (the transgenic line PHIL) have reduced airway le...
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Chemokine receptors transduce signals important for the function and trafficking of leukocytes. Recently, it has been shown that CC chemokine receptor (CCR)8 is selectively expressed by Th2 subsets, but its functional relevance is unclear. To address the biological role of CCR8, we generated CCR8 deficient (-/-) mice. Here we report defective T helper type 2 (Th2) immune responses in vivo in CC...
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Department of Pathology, Hôpital Avicenne, APHP, Université Paris 13, 93009 Bobigny Cedex, France; Department of Histology, University of Medicine and Pharmacy, Craiova, Romania; URDIA, Service d'Anatomie Biomédicale des Saints Pères, Université Paris 5, 75006 Paris, France; Department of Pulmonary Medicine, Hôpital Avicenne, APHP, Université Paris 13, 93009 Bobigny Cedex, France; Laboratory ...
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Eosinophil arrest and recruitment to the airway in asthma are mediated, at least in part, by integrins. Eosinophils express α4β1, α6β1, αLβ2, αMβ2, αXβ2, αDβ2, and α4β7 integrins, which interact with counter-receptors on other cells or ligands in the extracellular matrix. Whether a given integrin-ligand pair mediates cell adhesion and migration depends on the activation state of the integrin. I...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2002
ISSN: 0002-9440
DOI: 10.1016/s0002-9440(10)64177-6